Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Wills Eye
Ingestion of caffeine in glaucoma patients and healthy subjects may decrease peripapillary and macular blood flow in the back of the eye.
The primary objective of this study is to assess the acute changes in peripapillary and macular blood flow before and after an intake of oral caffeine (200 milligram tablet) in glaucoma patients and healthy subjects by using optical coherence tomography angiography (OCTA) scans. This novel imaging tool creates three-dimensional angiograms to assesses signal changes caused by flowing blood cells in a non-invasive angiogram scan. Blood flow is shown as vessel density measured in percentage.
Age
18–90
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
age 18 to 90 years
diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced)
healthy subjects with no eye disease
You may not be if
Diseases, ophthalmic or systemic, that are likely to affect OCTA results
greater than moderate cataract
nystagmus
inability to look at target
macular degeneration other than mild drusen or pigmentary changes
diabetic retinopathy
neovascular glaucoma or non-glaucoma optic neuropathies
current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy
keratoconus, corneal ectasia, central corneal scarring
rheumatologic diseases or Raynaud's phenomena
pregnant and lactating women
mental illness or alcohol addiction
pre-existing bladder symptoms, cardiac disease or sleep disorder
refractive spherical diopter greater than 5 or cylinder greater than 3
possible tolerance to caffeine (drinking more than 1 cup coffee per day).
