Saves the questions and what to expect into your notes, next to the visit they belong to.
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Lead
NYU Langone Health
This early phase I trial studies how well indwelling pleural catheters with doxycycline work compared to indwelling pleural catheters alone in treating participants with malignant pleural effusions. These types of catheters are commonly used to treat pleural effusions (build-up of fluid in the lungs). Doxycycline is an antibiotic that is also used to treat pleural effusions. It is not yet known whether giving doxycycline with indwelling pleural catheters works better than indwelling pleural catheters alone in treating participants with cancerous pleural effusions.
Age
18–100
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Outpatients with MPE undergoing IPC placement
Sufficient mental capacity to provide informed consent and answer Short-Form Six-Dimension health index (SF-6D) and Borg score questions
You may not be if
Patients undergoing pleurodesis for benign disease (e.g., spontaneous pneumothorax)
Inability or unwillingness to give informed consent
Inability to perform phone call and clinical follow-up at MD Anderson Cancer Center (MDACC)
Pregnancy
Previous intrapleural therapy for MPE on the same side
Eastern Cooperative Oncology Group (ECOG) of 4 and life expectancy ≤ 2 weeks
Doxycycline allergy
Extensive loculations or hydropneumothorax or other contraindication to pleurodesis
Chylous effusions associated with malignant disease