Previous systemic treatment for PC except ADT started within 3 months before randomization

Previous radiotherapy to the pelvis interfering with prostate irradiation

Previous surgery in the pelvis interfering with radical prostatectomy

Symptoms related to metastatic lesions, persisting for at least 2 weeks after initiation of ADT

Metastatic brain disease, leptomeningeal disease or imminent spinal cord compression

Previous or current malignant disease which is likely to interfere with LoMP II treatment or assessment

Psychological disorder intervening with understanding the information or the informed consent

Cytoreductive Prostatectomy Versus Cytoreductive Prostate Irradiation As a Local Treatment Option for Metastatic Prostate Cancer: a Multicentric Feasibility Trial