A Study of ABBV-011 Alone and in Combination With Budigalimab (ABBV-181) in Participants With Relapsed or Refractory Small Cell Lung Cancer

Exclusion Criteria

• •History of confirmed or suspected liver cirrhosis, hepatic veno-occlusive disease (VOD), sinusoidal obstruction syndrome (SOS), alcohol dependence, or ongoing excessive alcohol use.
• •Prior history of allogeneic or autologous stem cell transplantation.
• •Documented history of stroke or clinically significant cardiac disease as described in the protocol within 6 months prior to the first dose of study drug.
• •History of cardiac conduction abnormalities as described in the protocol.
• •Recent or ongoing serious infection, as described in the protocol.
• •Active SARS-CoV-2 infection.
• •Prior or concomitant malignancies with some exceptions, as described in the protocol.
• •Any significant medical or psychiatric condition, including any suggested by Screening laboratory findings, that in the opinion of the Investigator or Sponsor may place the participant at undue risk from the study treatment, interfere with interpretation of study results, or compromise ability to comply with protocol requirements.
• •Participants with a history of hypersensitivity to the active ingredients or any excipients of study drugs (ABBV-011 or budigalimab \[ABBV-181\]) will be excluded.
• •History of inflammatory bowel disease.
• •Peripheral neuropathy Grade 2 with pain, or Grade 3 or higher.
• •Body weight less than 35 kilograms.
• •Active pneumonitis or interstitial lung disease (ILD) or a history of pneumonitis/ILD requiring treatment with steroids.
• •Participants previously treated with an anti PD-1/PD-L1 targeting agent must meet additional criteria described in the protocol.
• •Participant is judged by the Investigator to have evidence of ongoing hemolysis.
• •Immunosuppressive use with exceptions as per protocol.
• •Participants who have received a live vaccine within 30 days of start of study treatment.
• •Active autoimmune disease with exceptions as indicated in the protocol.
• •History of primary immunodeficiency, solid organ transplantation, or previous clinical diagnosis of tuberculosis.
• •Participants with a history of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reaction with eosinophilia and systemic symptoms (DRESS).
• •\- Participants with a history of interstitial lung disease (pneumonitis) or current interstitial lung disease (pneumonitis).