Efficacy and Safety of Nebivolol Versus Metoprolol in Hypertensive Subject Taking Amlodipine

Exclusion Criteria

• •Known allergy or hypersensitivity to Beta Blockers.
• •Known allergy or hypersensitivity to Calcium Channel Blockers.
• •Patients with severe hypertension (mean seated cuff Diastolic blood pressure \> 115 mmHg or mean seated Systolic blood pressure \>180 mmHg) or any form of secondary hypertension.
• •Patients within the past 6 months with a history of hypertensive encephalopathy, stroke or transient ischemic attack.
• •Patients within the last 6 months with a history of myocardial infarction, percutaneous trans luminal coronary revascularization, coronary bypass graft, valvular surgery or unstable angina.
• •Patients with evidence of resting bradycardia (\<50 bpm) via palpation.
• •Patients with a history of heart block greater than First Degree Sino atrial Block. Wolff-Parkinson-White Syndrome, Sick Sinus Syndrome, Atrial Fibrillation, Atrial Flutter, Congestive Heart Failure, or other manifestations of clinically significant cardiac valvular disease.
• •Patients with hemodynamically significant cardiac valvular disease.
• •Patients with evidence of significant chronic renal impairment as indicated by a serum creatinine of \> 2.5mg/dL
• •Patients with evidence of liver disease as indicated by AST (SGOT) or ALT (SGPT) \> 2.5 times or total bilirubin \> 1.5 times, the upper limit of the laboratory normal range.
• •Patients who demonstrate other laboratory test values deviating from the Normal range which are considered to be clinically significant by the investigator.
• •Patient with a history or presence of gastrointestinal disease which may interfere with drug absorption.
• •Patients with insulin and non-insulin dependent diabetes mellitus not controlled on diet, insulin or oral hypoglycemic as defined by a HgA1c \>10.
• •Severe psychological or emotional condition which may interfere with participation in the study.
• •History of or current use of illicit drugs or alcohol abuse.
• •Participation in a clinical trial and taking any investigation drug within 30 days prior to enrolling into the study (Screening Visit).
• •A physical condition that would limit accurate BP measurement.
• •Inability to swallow a tablet or capsule.
• •History of moderate or sever asthma or Chronic obstructive pulmonary disease.
• •Any other medical condition which, in the Investigator's opinion, may render the patient unable to complete the study or which would interfere with optimal participation in the study or produce significant risk to the patient.