Generation of Thrombin and Prediction of Deep Vein Thrombosis Post Prosthetic Orthopedic Surgery of the Lower Limbs

Exclusion Criteria

• •The patient is participating in another interventional study.
• •The patient is in an exclusion period determined by a previous study.
• •Minor patients, people in emergency situations.
• •The patient is under the protection of justice, guardianship or curatorship.
• •The patient refuses to sign the consent.
• •It is not possible to inform the patient.
• •The patient is pregnant, parturient, or breastfeeding.
• •The patient has a contraindication (or incompatible drug combination) to drug thromboprophylaxis applied according to good clinical practice and recommendations of learned societies
• •Long-term anticoagulant therapy for personal thrombotic history.
• •Known hemorrhagic disease.
• •Haemorrhagic risk perceived during the consultation of preoperative anesthesia, leading to modify / develop the usual thromboprophylaxis.
• •Chronic liver disease.
• •Chronic renal failure with calculated clearance \<30 ml / min.
• •Extreme body mass index: \<18 kg.m-2 or\> 40 kg.m-2
• •total hip prosthesis or total knee prosthesis in the immediate aftermath of a bone fracture.
• •total hip prosthesis resumption.
• •Installation of more than one joint prosthesis.
• •Surgery in the previous 3 months.
• •Infective push in the previous 3 months.
• •Indication of haemostatic treatment for abnormal haemorrhagic risk.
• •Severe impairment of renal function with a calculated clearance \<30 ml / min.
• •Contraindication (allergic, metabolic, other ...) to usual drug thromboprophylaxis.
• •Condition requiring dosage adjustment of drug thromboprophylaxis.
• •Indication to put in place intermittent pneumatic compression for perioperative thromboprophylaxis.