Soy and Brain Vascular Function

Exclusion Criteria

• •Allergy or intolerance to soy
• •Current smoker, or smoking cessation \< 12 months
• •Diabetic patients
• •Familial hypercholesterolemia
• •Abuse of drugs
• •More than 3 alcoholic consumptions per day
• •Use of soy products or dietary supplements known to interfere with the main outcomes as judged by the principal investigators
• •Use medication to treat blood pressure, lipid or glucose metabolism
• •Use of an investigational product within another biomedical intervention trial within the previous 1-month
• •Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis
• •Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident
• •Contra-indications for MRI imaging (e.g. pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia)