The Efficacy of Salvage BGD With autoSCT Consolidation in Advanced Classical HL Patients Not Responding to ABVD

Exclusion Criteria

• •Non-Classical Hodgkin's Lymphoma
• •Other than ABVD first-line treatment, preceding patient's inclusion
• •Lack of PET scans performed in accordance with inclusin criteria during ABVD treatment
• •Transformation of Hodgkin's Lymphoma
• •Central Nervous System (CNS) Metastases
• •Contraindications for ASCT or lack of patient's consens for the procedure
• •Second malignancy - active or cured less than 5 years prior
• •Uncontrolled diabetes
• •Hepatic impairment (bilirubin concentration ≥ 1.5 x ULN, SGOT \> 5 x ULN), if non-realted to the lymphoma or Gilbert's syndrome
• •HIV infection
• •Active HBV or HCV infection. Subjects who have had Hepatitis B and are abHBC positive, need to undergo HBV DNA test using a Polymerase Chain Reaction (PCR) technique and be applied appropriate preventive treatment.
• •Pregnancy or lactation
• •Hypersensitivity to any of the drugs
• •Lack of written informed consent