A Clinical Trial of Metformin in the Maintenance of Non-Hodgkin's Lymphoma Patients

Exclusion Criteria

• •1. Past medical history of high doses of cytarabine, methotrexate and rituximab maintenance therapy;
• •2. Past medical history of any type of hematopoietic stem cell transplantation;
• •3. Past medical history of lactic acidosis;
• •4. Extreme weight loss failure, malnutrition or dehydration patients;
• •5. Pregnant women or lactating women, or women who do not take contraceptive measures for childbearing age;
• •6. Alopecia, mental retardation or psychiatric disorders that affect the patient's normal informed consent;
• •7. Type 1.2 diabetes with ketoacidosis, liver function or renal insufficiency, pulmonary insufficiency, heart failure, acute myocardial infarction, severe infection and trauma, major surgery and clinical hypotension or hypoxia;
• •8. Diabetes complicated with severe chronic complications (such as diabetic nephropathy, diabetic retinopathy);
• •9. Any other serious complications occurred, depending on the outcome of the study;
• •10. Before the intravenous pyelography or anterior angiography;
• •11. Alcoholics;
• •12. Deficiency of Vitamin B12, folic acid or iron.