A New Nutritional Countermeasure to Prevent the Deconditioning Induced by 60 Days of Antiorthostatic Bed Rest

Exclusion Criteria

• •\- Past record of orthostatic intolerance,
• •Cardiac rhythm disorders,
• •Chronic back pains,
• •History of hiatus hernia or gastro-esophageal reflux,
• •History of thyroid dysfunction, renal stones, diabetes, migraines,
• •Past records of thrombophlebitis, family history of thrombosis or positive response in thrombosis screening procedure,
• •Allergy including xylocaine allergy
• •Abnormal result for lower limbs echo-doppler,
• •History or active claustrophobia,
• •History of genetic muscle and bone diseases of any kind,
• •History of sleep disorders, no shift work or travel across more than one time zone in previous two months
• •Vestibular disorders,
• •Audition problem,
• •Vision corrected no more than 20/30, color-blindness
• •Bone mineral density: T-score ≤ -1.5,
• •Osteosynthesis material, presence of metallic implants,
• •History of knee problems or joint surgery/broken leg
• •Poor tolerance to blood sampling,
• •Having given blood (more than 8ml/kg) in a period of 8 weeks or less before the start of the experiment,
• •Special food diet, vegetarian or vegan, food allergy especially allergic to peanut or soya.
• •Positive reaction to any of the following tests: HVA IgM (hepatitis A), HBs antigen (hepatitis B), anti-HVC antibodies (hepatitis C), anti-HIV1+2 antibodies,
• •Subject already participating or in the exclusion period of a clinical research,
• •Refusal to give permission to contact his general practitioner,
• •Incarcerated persons,
• •Subject who, in the judgment of the investigator, is likely to be non-compliant during the study, or unable to cooperate because of a language problem or poor mental development,
• •Subject who has received more than 4500 Euros within 12 months for being a research subject.
• •Subject under guardianship or trusteeship.