Task Control Circuit Targets for Obsessive Compulsive Behaviors in Children

Inclusion Criteria

• •Obsessive-Compulsive Disorder (OCD) patient group
• •INCLUSION:
• •1. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Diagnosis of OCD as the principal problem
• •2. Not on psychotropic medication and not receiving current psychotherapy for OCD
• •3. Written informed assent by the participants and consent by the parent
• •4. Participants and a parent/guardian must be able to read and understand English
• •EXCLUSION
• •1. DSM-5 current diagnosis of major depressive disorder, or substance/alcohol abuse
• •2. DSM-5 lifetime diagnosis of psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, or substance/alcohol abuse
• •3. Individuals who are currently receiving CBT, other forms of psychotherapy, or psychotropic medications (stable doses of stimulants or other types of ADHD medications - e.g. Guanfacine - are allowable for OCD subjects with comorbid attention deficit hyperactivity disorder following investigator review of medication; on day of study scan, subjects must be willing to refrain from taking medication until after scan is completed)
• •4. Active suicidal ideation
• •5. Females who are pregnant or nursing
• •6. Major medical or neurological problems
• •7. Presence of metallic device or dental braces
• •8. Intelligence Quotient (IQ)\<80
• •9. A current or past diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• •10. Individuals who are currently receiving CBT, other forms of psychotherapy, or psychotropic medications
• •11. Individuals who have received a full course of CBT in the past
• •12. A positive pregnancy test
• •13. Positive urine screen for illicit drugs
• •Healthy controls
• •INCLUSION:
• •1. Written informed assent by the participants and consent by the parent
• •2. Participants and a parent/guardian must be able to read and understand English
• •EXCLUSION:
• •1. Any current or lifetime psychiatric diagnosis
• •2. Active suicidal ideation
• •3. Females who are pregnant or nursing
• •4. Major medical or neurological problems
• •5. Presence of metallic device or dental braces
• •6. IQ \<80
• •7. A current or past diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• •8. A positive pregnancy test
• •9. Positive urine screen for illicit drugs
• •Obsessive Compulsive Symptoms
• •INCLUSION:
• •1. Presence of obsession(s) and/or compulsion(s) but no current diagnosis of OCD (i.e.,\<1 hour/day, no more than mild interference or distress)
• •2. Not on psychotropic medication and not receiving current psychotherapy for OCD
• •3. Written informed assent by the participants and consent by the parent
• •4. Participants and a parent/guardian must be able to read and understand English
• •EXCLUSION:
• •1. DSM-5 current diagnosis of major depressive disorder, attention-deficit hyperactivity disorder, Tourette's/Tic Disorder, or substance/alcohol abuse
• •2. DSM-5 lifetime diagnosis of psychotic disorder, bipolar disorder, eating disorder, pervasive developmental disorder, or substance/alcohol abuse
• •3. Active suicidal ideation
• •4. Females who are pregnant or nursing
• •5. Major medical or neurological problems
• •6. Presence of metallic device or dental braces
• •7. IQ\<80
• •8. A current or past diagnosis of pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS)
• •9. Individuals who are currently receiving CBT, other forms of psychotherapy, or psychotropic medications
• •10. Individuals who have received a full course of CBT in the past
• •11. Positive urine screen for illicit drugs