FOLFOX + Panitumumab According to a "Stop and go" Strategy With a Reintroduction Loop After Progression on Fluoropyrimidine as Maintenance Treatment, as the First Line in Patients With Metastatic Colorectal Adenocarcinoma Without a RAS Mutation

\- Presence of uncontrolled symptomatic brain metastases

RAS mutation (KRAS or NRAS mutation)

Patient taking warfarin. If treated with anticoagulant at the indicated effective dose, this must be replaced with low molecular weight heparin before inclusion

Known DPD deficiency

Peripheral neuropathy \> 1 (NCI CTCAE v4.0)

Patient with interstitial pneumonitis or pulmonary fibrosis

History of chronic diarrhoea or inflammatory disease of the colon or rectum, or obstruction or sub-obstruction during symptomatic treatment

Poorly controlled chronic skin disease

Any known specific contraindication or allergy to the medicinal products used in the study

Patient simultaneously included in another clinical trial involving an investigational drug (example: chemotherapy, targeted therapy, immunotherapy)

Arterial hypertension not controlled by medical treatment (Systolic BP ≥ 160 mmHg end/or diastolic BP ≥ 90 mmHg)

Any progressive pathology not stabilised over the past 6 months: hepatic failure, renal failure, respiratory failure

The following conditions in the 6 months prior to inclusion: myocardial infarction, severe/unstable angina, coronary artery bypass surgery, congestive heart failure NYHA class II, III or IV, stroke or transient ischaemic attack

Patient who has received a transplant, is seropositive for HIV, hepatitis B or hepatitis C or has other immunodeficiency syndromes

History of malignant pathologies during the past 5 years except basal cell carcinoma of the skin or cervical carcinoma in situ, properly treated

QT/QTc interval \> 450 msec for men and \> 470 msec for women

K+ \< LNL, Mg2+ \< LNL, Ca2+ \< LNL

Lack of effective contraception in patients (men and/or women) of childbearing age, pregnant or breastfeeding women, women of childbearing age who have not had a pregnancy test

Persons in custody or under wardship

Impossibility of undergoing medical monitoring during the trial for geographical, social or psychological reasons

What this study is about