Atrial FIbrillation Treatment With Cryoballoon in Heart failurE (AFICHE)

Exclusion Criteria

• •previous left atrial ablation,
• •left atrial diameter \>28 mm/m2 BSA on TTE (parasternal long axis view),
• •strong clinical suspicion that reduced LVEF is primarily due to tachycardiomyopathy,
• •pre-existing device (ICD or CRT) without AF detection algorithms and/or (for CRT devices) diagnostics of effective biventricular pacing,
• •known primary electrical heart disease (e.g. Brugada syndrome),
• •presence of thrombus in a heart chamber,
• •presence of prosthetic valve at any position,
• •moderate/severe valvular heart disease,
• •active infectious disease or malignancy,
• •moderate or severe hepatic impairment (Child-Pugh class B or C),
• •severe renal failure (estimated glomerular filtration rate \<20 ml/min/1.73 m2),
• •inability or unwillingness to adhere to standard treatment or to provide consent.