PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST)

Exclusion Criteria

• •i) Known Hypersensitivity to FRAGMIN (Dalteparin), or its constituents including benzyl alcohol or to other low molecular weight heparins and/or heparins or pork products
• •ii) Known history of confirmed or suspected immunologically-mediated heparin-induced thrombocytopenia (delayed-onset severe thrombocytopenia), and/or in patients with a known history of a positive in vitro platelet-aggregation test in the presence of FRAGMIN (Dalteparin) is positive
• •iii) Known septic endocarditis
• •iv) Uncontrollable active bleeding
• •v) Known major blood clotting disorders
• •vi) Known acute gastroduodenal ulcer (with active bleeding)
• •vii) Severe uncontrolled hypertension (i.e. BP\>210 despite medications)
• •viii) Known diabetic or hemorrhagic retinopathy
• •ix) Anticipated to be unable to receive SCD on at least one lower extremity due to nature of injuries for duration of intervention period
• •x) Presence of another confounding factor that can adequately explain the poor GCS at time of presentation (e.g. drug toxicity, seizure)
• •xi) Known presence of irreversible coagulopathies
• •xii) Known Pregnancy
• •xiii) Participants extremely low weight (\<45 kg), or extremely high weight (\>120kg)
• •xiv) Not expected to survive more than 48 hours from admission