ECT in Ultra-resistant Schizophrenia

Inclusion Criteria

• •Patients with URS: patients who continue to experience persistent positive psychotic symptoms: item score of 4 (moderate) on at least two of four positive symptoms on the BPRS (grandiosity, suspiciousness, hallucinations and unusual thoughts), current presence of at least moderately severe illness on the total BPRS-18 (45) and a score of 4 (moderate) on the CGI-S, despite a period of clozapine therapy of at least 6 weeks with a plasma concentration of 350 ng/ml and at least two unsuccessful previous treatment trials with conventional or atypical antipsychotic drugs from two distinct families at a dose 600 mg of chlorpromazine equivalents.
• •Age: from 18 to 55
• •Patients with stable treatments for at least 8 weeks (antipsychotics, mood stabilizers and antidepressants).
• •Participants who gave their informed, written consents and agreement of their guardian for the patients under guardianship
• •Patients deprived of liberty if they gave their informed, written consents