Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder

Inclusion Criteria

• •1. Age 18-65 years old
• •2. Meets the DSM-5 criteria for diagnoses of schizophrenia or schizoaffective disorder and substance use disorder (alcohol, cocaine, heroin, or cannabis) based on the Mini International Neuropsychiatric Interview for the DSM-5 (MINI 7.0)
• •3. Uses substance on at least 4 of the past 30 days prior to randomization with at least one use in the week prior to randomization for one of substances (cocaine, heroin, cannabis or alcohol) assessed by the TLFB interview
• •4. Stable dose of antipsychotic agent for at least one month
• •5. Well established compliance with outpatient medications
• •6. Female subjects of child-bearing potential are required to practice appropriate birth control methods during the study.