A Study of Tirzepatide (LY3298176) in Participants With Impaired Kidney Function

Exclusion Criteria

• •All Participants:
• •* Women of childbearing potential
• •* Have known allergies to tirzepatide or related compounds
• •* Have a personal or family history of medullary thyroid carcinoma or have multiple endocrine neoplasia syndrome type 2
• •* Have serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \>2× the upper limit of normal (ULN) or total bilirubin (TBL) \>1.5× ULN
• •* Have a history or presence of pancreatitis (history of chronic pancreatitis or idiopathic acute pancreatitis), elevation in serum amylase or lipase or GI disorder (eg, relevant esophageal reflux or gall bladder disease) or any GI disease which impacts gastric emptying (eg, gastric bypass surgery, pyloric stenosis, with the exception of appendectomy) or could be aggravated by glucagon-like peptide-1 (GLP-1) analogs or dipeptidyl peptidase IV (DPP-IV) inhibitors
• •Participants with Renal Impairment or ESRD:
• •* Have hemoglobin \<8.5 grams per deciliter (g/dL) or significant active hematological disease from causes other than underlying renal disease.
• •* Have used any drug indicated for medical care of the participant's renal impairment, which is not established in dose and administered for at least 7 days before LY3298176 administration
• •Participants with T2DM and Renal Impairment or ESRD:
• •* Have taken any glucose-lowering medications other than metformin, including insulin, in the past 3 months before screening
• •* Have had more than 1 episode of severe hypoglycemia, as defined by the American Diabetes Association criteria, within 6 months before entry into the study or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms