Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection

Exclusion Criteria

• •History of hypersensitivity or allergy to oral vancomycin.
• •Current use of oral vancomycin
• •Patients on concurrent treatment with metronidazole or tetracycline monotherapy for any indication
• •Patients diagnosed with inflammatory bowel disorder (Crohn's disease), or bacterial gastrointestinal infection cause by agents other than C. difficile (e.g. Salmonella sp.), toxic megacolon and/or known small bowel ileus.
• •Dysphagia (inability to swallow capsules) or unwilling to swallow capsules.
• •Major gastrointestinal surgery within 3 months of enrollment (does not include appendectomy or cholecystectomy).
• •Any history of total colectomy or bariatric surgery.
• •Unable or unwilling to fulfill study requirements.
• •Expected life expectancy \< 6 months.
• •Patients enrolled in another clinical trial with investigational drugs within 30 days prior to randomization.
• •Women who are pregnant or breast-feeding.
• •Any patient deemed not suitable for study participation at the discretion of the study investigator.
• •Diarrhea (3 or more loose stools in a 24 hour period) at enrollment.