CardiAMP Cell Therapy Chronic Myocardial Ischemia Trial

Inclusion Criteria

• •1. Male or female 21 to 80 years of age
• •2. Canadian Cardiovascular Society (CCS) class III or IV chronic refractory angina.
• •3. Lack of control of angina symptoms despite maximum tolerated doses of anti-angina drugs.
• •4. Evidence of inducible myocardial ischemia on baseline stress testing
• •5. Obstructive coronary disease unsuitable for conventional revascularization
• •6. Experience angina episodes at a minimum of 7 angina episodes per week (during a 4-week screening period).
• •7. Able to complete an exercise tolerance test on the treadmill
• •8. Left ventricular ejection fraction of greater than or equal to 40% as measured by echocardiography.
• •9. Qualification of a pre-procedure screening of bone-marrow aspiration