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COMPLETEDNCT03454568

The Patients' Experience After Stem Cell Transplant

This study will examine how adults ≥ 60 years old thinking and memory abilities are affected by stem cell transplant; whether these changes affect day-to-day activities and quality of life and how thi...

Lead sponsor: University of Nebraska•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Nebraska

In this study, the investigators are looking to understand: 1) how adults ≥ 60 years old thinking and memory abilities are affected by stem cell transplant; 2) whether these changes affect day-to-day activities and quality of life; and 3) how thinking and memory abilities are affected by genetics, depression, anxiety and physical function. Genetics and other factors may affect the brain's chemicals or structure, and may increase risk for negative effects on thinking and memory. Participants will undergo neurocognitive testing along with the collection of a saliva sample and completing a battery of questionnaires and assessments.

Age

60 - 85 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Between the ages of 60-85
•Diagnosed with a hematological malignancy
•Is considering an autologous or allogeneic stem cell transplant OR has undergone stem cell transplant in the past 12 months and seen by the PI for pre-transplant evaluation.
•Is able to read, write, speak, and understand English

Exclusion Criteria

•As per self report or medical record, history of central nervous system involvement and/or history of cranial irradiation or intrathecal chemotherapy except for patients with history of prophylactic intrathecal chemotherapy.
•As per self report or medical record, history of stroke, head injury, neurosurgery, seizure disorder, or demyelinating disorder.
•As per self report or medical record, history of substance use disorder.
•As per self report or in the judgement of the consenting professional, uncorrected vision loss.
•As per self report or medical record, primary psychiatric disorder necessitating inpatient treatment in the last 12 months.
•As per self report or medical record, history of allogeneic and or autologous stem cell transplant.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: January 8, 2026Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment110

Start dateSep 2017

Last updatedJan 8, 2026

Condition

Stem Cell Transplant Complications

Locations shown

University of Nebraska Medical Center

Omaha, Nebraska

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 8, 2026Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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