Pediatric MSC-AFP Sub-study for Crohn's Fistula

Exclusion Criteria

• •1. Inability to obtain informed consent (and assent where appropriate).
• •2. Clinically significant medical conditions within the six months before administration of MSCs: e.g. sepsis, pneumonia active serious infection or other conditions that would, in the opinion of the investigators, compromise the safety of the patient.
• •3. Specific exclusions;
• •a. Evidence of hepatitis B, C, or HIV
• •4. History of cancer including melanoma (with the exception of localized skin cancers)
• •5. Investigational drug within thirty (30) days of baseline
• •6. A resident outside the United States
• •7. Pregnant or trying to become pregnant, or breast feeding.
• •8. History of clinically significant auto-immunity (other than Crohn's disease) or any previous example of fat-directed autoimmunity
• •9. Previous allergic reaction to a perianal fistula plug.
• •10. If adipose tissue is not technically feasible
• •11. Weight less than 35 kg
• •12. Allergic to local anesthetics
• •13. Non-enterocutaneous tracts (i.e. recto-vaginal, entero-vesicular)