CPAP for OSA on Myocardial Salvage After pPCI for STEMI Patients

Exclusion Criteria

• •1. Prior myocardial infarction
• •2. Prior myocardial revascularization (PCI or CABG)
• •3. Cardiogenic shock (mean arterial pressure \<60mmHg), severe heart failure (Killip≥3)
• •4. LM or multivessel disease indicated for CABG
• •5. History of stroke
• •6. Severe insomnia, chronic sleep deprivation, abnormal circadian rhythm (sleep \<4h/night)
• •7. Severe COPD: FEV1/FVC \<70% or FEV1 \<50% predicted value (within 4 weeks)
• •8. Predominantly central sleep apnea (≥25% central events or central AHI ≥10/h)
• •9. Previous or current use of CPAP
• •10. Severe comorbidities: eg. malignancy (life expectancy \<2 years)
• •11. Known or planned pregnancy
• •12. Known contraindication to CMR
• •13. Patients with contraindication to CPAP or who cannot tolerate it
• •14. Participation in other clinical trial in recent 3 months
• •15. Any condition that in the opinion of investigator that may jeopardize patient compliance, eg. significant memory, perceptual, or behavioral disorder, depression, severe alcohol consumption, or a history of noncompliance