Eluxadoline Bile Acid Malabsorption (BAM) Study

Exclusion Criteria

• •Has a diagnosis of IBS with a subtype of irritable bowel syndrome with constipation (IBS-C), mixed IBS, or unsubtyped IBS per Rome IV criteria.
• •Does not have a gallbladder.
• •Has known or suspected biliary duct obstruction, or sphincter of Oddi disease or dysfunction. (Participants with a history of gallstones may be enrolled).
• •Has a history of alcoholism, alcohol abuse or alcohol addiction, or drinks more than 3 alcoholic beverages per day.
• •Has a history of pancreatitis; structural diseases of the pancreas, including known or suspected pancreatic duct obstruction.
• •Has a history of mild, moderate, or severe hepatic impairment according to Child-Pugh classification. History or current diagnosis of inflammatory or immune-mediated gastrointestinal (GI) disorders.
• •Has Celiac disease or a positive serological test for celiac disease.
• •Has known lactose or fructose intolerance associated with diarrhea, abdominal pain or discomfort, that could confound assessments in the study.
• •Women who are currently pregnant or nursing, or plan to become pregnant or nurse during the study.
• •Has known allergies or hypersensitivity to opioids.