This is a prospective trial of approximately 60 subjects with AERD to explore the mechanisms behind the physiologic reactions that occur when drinking alcoholic beverages. At various time points patients will be asked to ingest a variety of substances found in red wine after which blood and urine markers of the reaction will be measured.
Age
21–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Healthy Controls - must be 21 years or older
Aspirin Tolerant Asthma and AERD arms must note a sensitivity to alcoholic beverages
You may not be if
Enzymopathies
Mastocytosis
Alcoholism
Prior severe respiratory reaction to alcohol consumption
Current pregnancy
Monoamine Oxidase Inhibitor (MAOI) use
Age under 21
Use of leukotriene modifier 1 week before study intervention
Having undergone and maintained aspirin desensitization
Clareo Health | Mechanisms of Alcohol Sensitivity in AERD
