Cardiac Shock Wave Treatment in Patients With Reduced Coronary Flow Reserve

Exclusion Criteria

• •Participation in other clinical trials
• •age \<18 years
• •Contraindications to under cMRI
• •Contraindications to adenosine (severe chronic obstructive pulmonary disease (COPD), asthma, atrioventricular block (AV block) \> grade 1)
• •Left ventricular thrombus
• •Uncontrolled diabetes mellitus
• •Uncontrolled arterial hypertension,
• •Any other severe chronic illness such as liver or renal failure (glomerular filtration rate (GFR) \< 45 ml/min), active neoplastic disease, history of myocardial infarction or coronary revascularization within the past three months
• •Patients with pacemaker or implanted cardioverter defibrillator
• •Patients after valve surgical replacement
• •Patients after interventional valve replacement or reconstruction (e.g. transfemoral aortic valve replacement or MitraClip implantation)
• •Pregnancy (a reliable method of contraception must be used for the entire duration of the study)
• •Fertile female participants who are capable of bearing children and who do not use a method of contraception that is medically approved by the health authority of the respective country
• •Missing capacity to consent