A Study to Evaluate the Safety, Tolerability and Absorption to the Blood After Administration of Single and Multiple Doses of AZD8154 in Healthy Participants.

Exclusion Criteria

• •1. History of any clinically important disease or disorder which, in the opinion of the Investigator, may either put the subject at risk because of participation in the study, or influence the results or the subject's ability to participate in the study.
• •2. Subject is immuno-compromised.
• •3. History of diabetes, impaired fasting glucose, metabolic syndrome, hypertriglyceridemia or familial lipid disorders.
• •4. Current or previous history of malignancy of any kind except cutaneous basal or squamous cell carcinoma successful treated with therapy.
• •5. History of any respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF).
• •6. Subject with latent or active tuberculosis (TB), as conformed by a positive QuantiFERON® - TB Gold test or as judged by the Investigator at the Screening Visit.
• •7. History or presence of GI, hepatic or renal disease or any other condition known to interfere with absorption, distribution, metabolism or excretion of drugs, or bowel disorders not otherwise specified.
• •8. Any clinically important illness, medical/surgical procedure or trauma within 4 weeks of the (first) administration of the IMP.
• •9. Any clinically important abnormalities in clinical chemistry, hematology or urinalysis results, defined as the following:
• •9.1. Alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) \> the upper limit of the normal (ULN) laboratory range.
• •9.2. Bilirubin \> 1.5 times the ULN laboratory range. 9.3. Absolute neutrophil count \< lower limit of normal (LLN). 9.4. Absolute lymphocyte count \< LLN. 9.5. Fasting plasma glucose \> ULN. 9.6. Triglycerides \> ULN.
• •10. Any positive result at the Screening Visit for serum hepatitis B surface antigen (HBsAg) OR hepatitis B core antibodies (anti-HBc), hepatitis C antibody and human immunodeficiency virus (HIV).
• •11. Abnormal vital signs, after 5 minutes supine rest, defined as any of the following:
• •11.1. Systolic BP \< 90 mmHg or \> 140 mmHg. 11.2. Diastolic BP \< 50 mmHg or \> 90 mmHg. 11.3. Heart rate \< 50 or \> 90 beats per minute (bpm).
• •12. Any clinically important abnormalities in rhythm, conduction or morphology of the 12-lead safety and any clinically important abnormalities in the 12-Lead dECG as considered by the Investigator that may interfere with the interpretation of QT interval corrected for heart rate using Fridericia's formula (QTcF) interval changes, including abnormal ST-T-wave morphology, particularly in the CSP defined primary lead for dECG analysis or left ventricular hypertrophy.
• •12.1. Prolonged QTcF \> 450 ms or shortened QTcF \< 340 ms or family history of long QT syndrome.
• •12.2. PR (PQ) interval shortening \< 120 ms (PR \> 110 ms but \< 120 ms is acceptable if there is no evidence of ventricular pre-excitation).
• •12.3. PR (PQ) interval prolongation (\> 220 ms) intermittent second (Wenckebach block while asleep is not exclusive) or third degree atrioventricular (AV) block, or AV dissociation.
• •12.4. Persistent or intermittent complete bundle branch block (BBB), incomplete bundle branch block (IBBB), or intraventricular conduction delay (IVCD) with QRS \> 110 ms. participants with QRS \> 110 ms but \< 115 ms are acceptable if there is no evidence of e.g., ventricular hypertrophy or pre-excitation.
• •13. Previous use of a mechanistic target of rapamycin (mTOR) antagonist (e.g., rapamycin, everolimus) or PI3K inhibitor (selective or non-selective PI3K inhibitors).
• •14. Known or suspected history of drug abuse as judged by the Investigator.
• •15. Current smokers or those who have smoked or used nicotine products (including e-cigarettes) within the previous 3 months.
• •16. History of alcohol abuse or excessive intake of alcohol as judged by the Investigator.
• •17. Positive screen for drugs of abuse or cotinine (nicotine) at the Screening Visit or admission to the Clinical Unit or positive screen for alcohol on admission to the Clinical Unit before the (first) administration of the IMP.
• •18. History of severe allergy/hypersensitivity or ongoing clinically important allergy/hypersensitivity, as judged by the Investigator or history of hypersensitivity to drugs with a similar chemical structure or class to AZD8154.
• •19. Receipt of live attenuated vaccines 2 months before (first) administration of the IMP and 3 months after the last IMP administration.
• •20. Excessive intake of caffeine-containing drinks or food (e.g., coffee, tea, chocolate) as judged by the Investigator.
• •21. Use of drugs with CYP3A enzyme inducing or inhibition properties such as St John's Wort within 3 weeks before (first) administration of IMP.
• •22. Use of any prescribed or nonprescribed medication including antacids, analgesics (other than paracetamol/acetaminophen), herbal remedies, megadose vitamins (intake of 20 to 600 times the recommended daily dose) and minerals during the 2 weeks before the (first) administration of the IMP or longer if the medication has a long half-life.
• •23. Plasma donation within 1 month of the Screening Visit or any blood donation/blood loss \> 500 mL during the 2 months before the Screening Visit.
• •24. Has received another new chemical entity (defined as a compound which has not been approved for marketing) within 3 months of the (first) administration the IMP in this study. The period of exclusion begins 3 months after the final dose or 1 month after the last visit whichever is the longest. Note: participants consented and screened, but not randomized in this study or a previous Phase 1 study, are not excluded.
• •25. Involvement of any Astra Zeneca or study site employee or their close relatives.
• •26. Judgment by the Investigator that the subject should not participate in the study if they have any ongoing or recent (i.e., during the Screening Period) minor medical complaints that may interfere with the interpretation of study data or are considered unlikely to comply with study procedures, restrictions and requirements.
• •27. Participants who cannot communicate reliably with the Investigator and/or is not able to read speak and understand German language.
• •28. Vulnerable participants, e.g., kept in detention, protected adults under guardianship, trusteeship or committed to an institution by governmental or juridical order.
• •In addition, any of the following is regarded as a criterion for exclusion from the genetic research:
• •29. Previous bone marrow transplant.
• •30. Non-leukocyte depleted whole blood transfusion within 120 days of the date of the genetic sample collection.