Radiation-hormone and Docetaxel VS Radiation-hormone in Patients With High-Risk Localized Prostate Cancer

Inclusion Criteria

• •1. Histological confirmation of adenocarcinoma of the prostate.
• •2. Age \> 18 years.
• •3. Localized high-risk prostate cancer, defined as:
• •* Stage III: T3 N0 M0, Gleason grade 8, 9, or 10, or
• •* Stage IV: T4 N0 M0, any Gleason grade or Tx N1 M0, any Gleason grade
• •4. PSA \> 20 ng/mL.
• •5. Karnofsky index ≥ 70%
• •6. Good bone marrow reserve, with white blood cell count \> 3000/mm3, hemoglobin \>9.5 g/dL and platelets \> 150,000/mm3.
• •7. Absence of hepatic abnormality, with bilirubin values \< 1.5 mg/dL and with SGOT/SGPT values up to 2 times the upper limit of normality for each site.
• •8. Absence of abnormality in renal function, with creatinine levels up to 2 times the upper limit of normality for each site.
• •9. Having given informed consent in writing.