Antioxidant Supplements, Genetics and Chemotherapy Outcomes

Inclusion Criteria

• •Histologically confirmed diagnosis of operable Stage 1, II, or III invasive breast cancer with known estrogen or progesterone receptor status
• •high risk by meeting at least one of the following criteria:
• •1. tumor \>= 2 cm in greatest diameter
• •2. one or more axillary or intramammary nodes are involved by metastatic breast cancer
• •had either a modified radical mastectomy or local excision of all tumors plus axillary node dissection or sentinel node resection
• •not received prior chemotherapy or radiation therapy for the current malignancy
• •no history of congestive heart failure or angina pectoris
• •normal creatinine and bilirubin, alkaline phosphatase and SGOT or SGPT 2 x the institutional upper limits of normal
• •ANC greater than or equal to 1,200 ul and platelet count of greater than or equal 100,000 U1
• •No previous malignancies
• •Age 18 or greater
• •Performance status of 0 -2 by Zubrod criteria
• •HIV negative (if known)