rTMS Treatment for Positive and Negative Symptoms of Schizophrenia

Exclusion Criteria

• •1. do not pass the TASS Safety Screening Questionnaire
• •2. have a significant history of seizures
• •3. have active suicidal intent
• •4. are pregnant or may be pregnant. A pregnancy test will be performed for fertile women.
• •5. have failed a course of Electroconvulsive Therapy (ECT) in the current or previous episode
• •6. have any significant neurological disorder or insult including, but not limited to: any condition likely to be associated with increased intracranial pressure, space occupying brain lesion, any history of seizure except those therapeutically induced by ECT, cerebral aneurysm, Parkinson's disease, Huntington's chorea, multiple sclerosis, or head trauma resulting in loss of consciousness greater than or equal to 5 minutes
• •7. have an intracranial implant (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object within or near the head, excluding the mouth, that cannot be safely removed
• •8. have had changes in dose or initiation of any psychotropic medication in the 4 weeks prior to screening. Patients may be re-screened once medications have been stable for 4 weeks.
• •9. currently (or in the last 4 weeks) take more than lorazepam 2 mg daily (or equivalent) or any dose of an anticonvulsant due to the potential to limit rTMS efficacy