A Multi-Center Study on the Metoprolol Optimal Dosing Pathway of Metoprolol Application in Chinese Patients With Acute Coronary Syndrome

Exclusion Criteria

• •Cardiac shock;
• •Unstable heart failure;
• •Beta-agonist therapy on a continuous or intermittent basis;
• •Hypotension (BP\<90/60 mmHg) or bradycardia (HR\<50 bpm) with symptoms;
• •Sick sinus syndrome;
• •Ⅱ\~Ⅲ atrioventricular block;
• •Killip \>Ⅱ;
• •Suspected acute myocardial infarction with heart rate\<45 beats/min, P- R interval\>0.24 sec or systolic blood pressure \<100 mmHg;
• •Existing contraindication for metoprolol or allergic to metoprolol or any excipients;
• •Participation in another clinical study with an investigational product during the last 3 months;
• •Previous enrolment in the present study;
• •Subjects the investigator thinks not suitable for this study. E.g. cancer etc.;
• •Inability to sign the informed consent form;
• •Pregnancy or lactation.