BCD With or Without Doxycycline in Mayo Stage II-III Light Chain Amyloidosis Patients

Exclusion Criteria

• •Co-morbidity of uncontrolled infection.
• •Co-morbidity of grade 2 or 3 atrioventricular block.
• •Co-morbidity of sustained or recurrent nonsustained ventricular tachycardia.
• •Co-morbidity of other active malignancy.
• •Co-diagnosis of multiple myeloma or waldenstrom macroglobulinemia.
• •Grade 2 or higher neuropathy according to National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0.
• •Allergic history of doxycycline.
• •Neutrophil \<1×10E9/L，hemoglobin \< 7g/dL，or platelet \< 75×10E9/L.
• •Severely compromised hepatic or renal function: ALT or AST \> 2.5 × ULN, total bilirubin \> 1.5mg/dL，or eGFR \< 60mL/min.