Trial of Oral Hyaluronic Acid for the Prevention of Aromatase Inhibitor-Associated Arthralgias

Primary Objective To determine whether oral HA will prevent AI-induced arthralgias and preserve physical function. Secondary Objectives 1. To explore whether oral HA will have an acceptable safety and tolerability profile. 2. To determine whether oral HA will prevent other AI associated symptoms as assessed by patient reported outcomes (PRO's). 3. To assess how many of the subjects are 90% compliant with taking the HA as directed. Exploratory Objective To determine if mi486, (a microRNA enriched in skeletal muscle) and other biomarkers associated with AIMSS (TNF, IL-6, IL-17) vary with the administration of HA.