Study to Compare Exposure of TA Following Administration of FX006 or TAcs in Patients With OA of the Shoulder or Hip

Exclusion Criteria

• •Reactive arthritis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, or arthritis associated with inflammatory bowel disease
• •History of infection in the index joint
• •Clinical findings consistent with active infection or crystal disease in the index joint within 1 month of Screening
• •History of fracture in the index limb within 12 months of Screening, or fracture with sequelae at any time
• •Planned or anticipated surgery of the index joint during the study period
• •Index joint instability or history of acute dislocation within 12 months of Screening
• •If shoulder is the index joint, history of full or partial rotator cuff tear or significantly compromised rotator cuff function that, in the opinion for the Investigator, increases the difficulty or risk of IA injection
• •Presence of surgical hardware or other foreign body in the index joint
• •Surgery or arthroscopy of the index joint within 12 months of Screening
• •IA treatment of any joint with any of the following agents within 6 months of Screening:
• •Any corticosteroid preparation (investigational or marketed, including FX006), any biologic agent (e.g., platelet rich plasma (PRP) injection, stem cells, prolotherapy, amniotic fluid injection; investigational or marketed)
• •IA treatment of the index joint with hyaluronic acid (investigational or marketed) within 6 months of Screening
• •Parenteral or oral corticosteroids (investigational or marketed) within 3 months of Screening
• •Inhaled, intranasal or topical corticosteroids (investigational or marketed) within 2 weeks of Screening
• •Females who are pregnant or nursing or plan to become pregnant during the study; men who plan to conceive during the study