A Study With LJPC-401 for the Treatment of Myocardial Iron Overload in Patients With Transfusion-Dependent Beta Thalassemia

Exclusion Criteria

• •Any significant medical condition or lab abnormality that would prevent the patient from participating in the study.
• •Pregnant or lactating women.
• •Patients taking an immunosuppressive agent (except topical over-the-counter steroids, inhaled steroid medications, and non-steroidal anti-inflammatory drugs) or have a planned surgery (except dental surgery or simple dermatologic procedures).
• •Patients participating in an unapproved investigational clinical trial within 30 days of this study.
• •Patients with a disease, disability or condition which may interfere with the conduct of the study, or which would, in the opinion of the Investigator, pose an unacceptable risk to the patient.
• •Patients who are unwilling or unable to comply with the study requirements.
• •Patients with known hepatitis B or hepatitis C, or being treated for a positive viral load or are noncompliant with hepatitis medications.
• •Known and active human immunodeficiency virus (HIV) infection.
• •Patients with Child Pugh class C cirrhosis or liver failure.
• •Patients with severe congestive heart failure (NYHA Class 4).
• •Use of erythropoiesis stimulating agents in the past 3 months prior to study entry.
• •History of allergic reaction to hepcidin or excipients.
• •Contraindication to MRI scanning.