Human Amniotic Epithelial Stem Cell in Treatment of Refractory Severe Intrauterine Adhesion

Exclusion Criteria

• •1\. Patients with severe internal disease;
• •2\. The patients are suffering from gynecologic inflammation or active genital tubercle bacillus;
• •3\. The patient has other uterine diseases or the abnormal uterine cavity which can't be restored by surgery;
• •4\. Infertility due to a man's cause;
• •5\. The patient has a previous history of cancer and is undergoing radiotherapy or chemotherapy;
• •6\. HIV positive
• •7\. Active hepatitis B or C infection, syphilis seropositive
• •8\. Laboratory routine check index abnormality, such as Hb（hemoglobin）\<8.0 g/dL,WBC（white blood cell count）\<3,000/ml, platelet counts\<75 000/mm3, AST（glutamic oxalacetic transaminase）\>ULN（upper limit of normal），ALT（Glutamic pyruvic transaminase）\>ULN and so on;
• •9\. Patients have any complications that may interfere with safety or efficacy or predict life expectancy of less than 24 months;
• •10\. Mental illness in the past 6 months;
• •11\. Patients have a history of drug or alcohol abuse or dependence in the past two years;
• •12\. Unable or unwilling to give informed consent.