Thermogenesis in Hyperthyroidism and Effect of Anti-Adrenergic Therapy

Exclusion Criteria

• •Contraindications to propranolol: hypersensitivity or allergy
• •Therapy with a beta blocker for reasons other than hyperthyroidism (e.g. cardiac arrhythmia or heart failure)
• •Treatment with amiodarone
• •Women who are pregnant or breast feeding,
• •Intention to become pregnant during the course of the study,
• •History of asthma or chronic obstructive pulmonary disease
• •Occlusive peripheral artery disease; Raynaud's syndrome.
• •Other clinically significant concomitant disease states:
• •* Known renal failure (GFR \< 50 ml/min)
• •* Known hepatic dysfunction
• •* known heart failure or unstable angina pectoris
• •Known or suspected non-compliance, drug or alcohol abuse,
• •Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant,
• •Participation in another study with investigational drug within the 30 days preceding and during the present study,
• •Previous enrolment into the current study,
• •Enrolment of the investigator, his/her family members, employees and other dependent persons.
• •ECG-criteria
• •* Resting heart rate below 60 bpm
• •* Complete left bundle branch block
• •* Atrioventricular block (AV-block) grade 2 or 3