Impact of Statin Therapy on Adaptations to Aerobic Exercise

Exclusion Criteria

• •Smoking
• •Use of statins in the last 6 months
• •Use of other medications or supplements that affect lipid profiles or body weight in the last 6 months (e.g., fibric acids, bile acid sequestrants, nicotinic acids, fish oil)
• •Diagnosis of chronic diseases including CVD, diabetes, other metabolic diseases (e.g., thyroid), cancer, HIV, or acquired immunodeficiency syndrome
• •History of abnormal bleeding problems
• •Currently taking (within the last 10 days) anti-platelet medication (Plavix), Warfarin, and other anti-coagulants (eliquis, pradaxa, and xarelto) medications
• •\>2 fold upper normal limit (UNL) for alanine aminotransferase (ALT) or creatinine
• •Women who are pregnant or breastfeeding
• •Individuals with polymorphisms known to be associated with susceptibility for statin induced myopathies (tested at screening)
• •Currently enrolled in another research study