The General Breathing Record Study

Inclusion Criteria

• •Asthma Cohort:
• •A confirmed clinical diagnosis of asthma for ≥ 6months
• •Moderate to severe asthma defined as British Thoracic Society stages 3-5
• •2 or more exacerbations in the previous 12 months with at least 1 exacerbation within the last 6 months.
• •Exacerbation free for 2 weeks (defined as no increased dose or course of oral corticosteroids or antibiotics).
• •Breathing Pattern Disorder Cohort
• •A Clinical diagnosis of a Breathing Pattern Disorder (BPD)
• •Chronic heart failure Cohort:
• •A confirmed clinical diagnosis of chronic heart failure with both of the following:
• •1. A Left Ventricular Ejection Fraction \<40% on most recent imaging within the last 12 months.
• •2. New York Heart Association Class 2-4
• •Admitted with an acute decompensation of their heart failure to hospital within the last 6 months
• •Motor Neurone Disease Cohort:
• •A confirmed clinical diagnosis of Motor Neurone Disease
• •Forced Vital Capacity (FVC) of less than 60% of predicted, sleep disordered breathing or daytime hypercapnia.
• •Established on Home Non-Invasive Ventilation.
• •Pneumonia Cohort:
• •A confirmed clinical diagnosis of Pneumonia supported by evidence of consolidation on a chest X-ray (CXR) or computed tomography (CT) imaging.
• •Healthy Cohort:
• •No known history of lung, cardiac or neuromuscular disease (defined as no current clinical diagnosis of, or be receiving treatment for, a lung, cardiac or neuromuscular disease). A Body Mass Index of less than 40. A Non-smoker, or an ex-smoker with less than a 5 pack year history.