PROspective Multicenter Observational Study on Elective Pelvic Nodes Irradiation.

Clinical features and outcomes of the patients included in the study will be assessed as better detailed in the following lines: 1. To define the diffusion of the practice of treating pelvic lymph-nodes in patients affected by intermediate/high/very high risk non-metastatic prostate cancer (PCa) among Italian Radiation Oncology Centers, submitted to radical or post-operative radiotherapy; 2. To define the diffusion of the different radiotherapy techniques used to treat pelvic nodes and the other features of the radiation treatment; 3. To register prospectively biochemical and clinical failure, prostate cancer deaths and deaths for any cause in the population studied; 4. To register prospectively the toxicity due to radiotherapy and androgen deprivation therapy in patients treated with pelvic nodes radiotherapy; 5. To compare clinical outcomes and toxicities observed in the different clinical and therapeutic subgroups with the corresponding historical data relative to PCa patients treated with radiotherapy with or without elective pelvic nodal irradiation, already available in the existing Italian Society of Radiation Oncology databases; 6. To exploit the collected data to define the need and the features of a prospective randomized trial evaluating the efficacy of elective pelvic nodal irradiation in patients with intermediate/high/very high risk non-metastatic prostate cancer.