Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed by Surgery

Exclusion Criteria

• •Any of the following:
• •* Individuals/or persons who are nursing
• •* Individual/or persons who are pregnant
• •* Individuals/or persons of childbearing potential who are unwilling to employ adequate contraception
• •Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens
• •Immunocompromised patients (other than that related to the use of corticosteroids) including patients known to be human immunodeficiency virus (HIV) positive
• •Prior history of receiving pazopanib or any other tyrosine kinase inhibitor treatments for malignancy
• •Uncontrolled intercurrent illness including, but not limited to:
• •* Chronic ongoing or active infection
• •* Symptomatic anemia
• •* Uncontrolled hypertension (defined as systolic blood pressure \[SBP\] of \>= 160 mmHg or diastolic blood pressure \[DBP\] of \>= 100 mmHg)
• •* Symptomatic congestive heart failure as defined by the New York Heart Association (NYHA) (does not exclude class III congestive heart failure \[CHF\])
• •* Unstable angina pectoris
• •* Cardiac arrhythmia
• •* Evidence of active bleeding or bleeding diathesis
• •* Psychiatric illness/social situations that would limit compliance with study requirements
• •* Any other serious uncontrolled medical disorders in the opinion of the investigator
• •History of a major thromboembolic event =\< 6 months prior to randomization, including cerebrovascular accident, transient ischemic attack (TIA), myocardial infarction, symptomatic pulmonary embolism (PE) or untreated deep venous thrombosis (DVT), or coronary artery bypass graft surgery; NOTE: Subjects with recent DVT or asymptomatic PE who have been treated with therapeutic anticoagulating agents for at least 6 weeks are eligible
• •Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm
• •Other active malignancy =\< 5 years prior to randomization; EXCEPTIONS: Nonmelanoma skin cancer or carcinoma-in-situ of the cervix, or cancers with low metastatic potential (e.g. Gleason score 6 prostate cancer) treated with curative therapy; NOTE: If there is a history or prior malignancy, they must not be receiving other specific treatment for their cancer
• •History or clinical evidence of central nervous system (CNS) metastases or leptomeningeal carcinomatosis, except for individuals who have previously treated CNS metastases, are asymptomatic, and have had no requirement for steroids or anti-seizure medication for =\< 6 months prior to randomization; Note: Screening with CNS imaging studies (computed tomography \[CT\] or magnetic resonance imaging \[MRI\]) is required only if clinically indicated or if the subject has a history of CNS metastases
• •Clinically significant gastrointestinal abnormalities that may increase the risk for gastrointestinal bleeding including, but not limited to:
• •* Active peptic ulcer disease
• •* Known intraluminal metastatic lesion/s with risk of bleeding
• •* Inflammatory bowel disease (e.g. ulcerative colitis, Crohn?s disease), or other gastrointestinal conditions with increased risk of perforation
• •* History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess =\< 28 days prior to randomization
• •* Clinically significant gastrointestinal abnormalities that may affect absorption of investigational product including, but not limited to:
• •* Malabsorption syndrome
• •* Any prior major resection of the stomach or small bowel
• •Corrected QT interval (QTc) \> 480 msecs using Bazett?s formula
• •Receiving any medications or substances with risk of Torsades de Pointes; Note: medications or substances on the list ?Drugs with Risk of Torsades de Pointes? are prohibited; medications or substances on the list ?Drugs with Possible or Conditional Risk of Torsades de Pointes? may be used while on study with extreme caution and careful monitoring
• •Treatment with any of the following anti-cancer therapies =\< 14 days prior to registration:
• •* Radiation therapy
• •* Surgery or tumor embolization
• •* Chemotherapy, immunotherapy
• •* Biologic therapy
• •* Investigational therapy
• •* Hormonal therapy
• •Prior autologous or allogeneic organ or tissue transplantation
• •Elective or planned major surgery to be performed during the course of the trial
• •Receiving any medications or substances that are strong or moderate inhibitors of CYP3A4; use of strong or moderate inhibitors are prohibited =\< 7 days prior to randomization
• •Receiving any medications or substances that are inducers of CYP3A4; use of inducers are prohibited =\< 7 days prior to randomization
• •Glucose-6-phosphate dehydrogenase (G6PD) deficiency (i.e. below normal limits)
• •End-stage renal disease (estimated glomerular filtration rate \[GFR\] \< 55 ml/min/body surface area \[BSA\]), unless the estimated creatinine clearance by Cockcroft Gault is \>= 55 ml/min prior to randomization
• •History of calcium oxalate stones
• •History of iron overload
• •Unable to swallow oral medications
• •History of myocardial infarction =\< 6 months, current symptomatic CHF or left ventricular ejection fraction (LVEF) \< 40% or \> grade 2 diastolic dysfunction, with no symptoms or signs of heart failure