Breast/Evaluation of Cryotherapy and TRPA1 Receptors in Chemotherapy Induced Neuropathy

Exclusion Criteria

• •Patients must not have received any prior taxane or platinum based chemotherapy.
• •Patients must not have a history of peripheral neuropathy (regardless of cause).
• •Patient must not have a history of Raynaud's disease.
• •Patients with partial or complete limb amputations.
• •Known hypersensitivity to cold
• •Patient cannot be on the following medications: GABA analogues (such as Neurontin, lyrica), tricyclic antidepressants (such as amitriptyline or nortriptyline)
• •As judged by the investigator, severe uncontrolled concurrent medical conditions, psychiatric illness or social condition that would limit compliance with study requirements.
• •Evidence of any significant clinical disorder or laboratory finding that makes it undesirable for the subject to participant in the clinical trial
• •Must not be pregnant or breast feeding