Allogenic platelet rich plasma (PRP) will be collected from blood group AB donors. This plasma will be tested for the presence of any chronic infectious blood borne disease.
Platelet lysate will be then prepared from the tested PRP to be intramuscularly injected in patients with PAD
Age
50–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Competent and willing to give informed consent, and to be available for all baseline treatment and follow up examinations required by the protocol.
Gender: Male or female.
Age group \> 50 years.
Established Critical limb ischemia (CLI), clinically and hemodynamically confirmed as per Rutherford 3, 4 and 5 with angiographic evidence of significant infra-inguinal arterial occlusive disease.
History of intermittent claudication for \> eight weeks.
Limited exercise due to moderate to severe claudication.
Resting ABI \< 0.6, toe pressure ≤ 60 mm Hg, Toe Brachial index (TBI) \<0.6, or TcPO2 ≤ 60 mmHg in the foot.
