Clinical Pharmacology Trial to Investigate the Dose of OPC-61815 Injection Equivalent to Tolvaptan 15-mg Tablet in Patients With Congestive Heart Failure

Inclusion Criteria

• •1. Subjects who are currently on treatment with any of the following diuretics
• •* Loop diuretics equivalent to furosemide tablet or fine granules at a dose of 40 mg/day or higher
• •* Concomitant use of a loop diuretic and a thiazide diuretic (including thiazide analogs) at any dose
• •* Concomitant use of a loop diuretic and an aldosterone antagonist or potassium-sparing diuretic agent at any dose
• •2. Subjects with congestive heart failure in whom lower limb edema, pulmonary congestion, and/or jugular venous distension due to volume overload is present
• •3. Subjects who are currently hospitalized or who are able to be hospitalized during the trial