Promising Bimarker Prediction of Outcome of HELLP Syndrome.

You may be eligible if

• Gestational age more than 20 weeks.
• Age from18 to 40 years old.
• Fulfilled criteria for the diagnosis of severe preeclampsia.
• Fulfilled criteria for the diagnosis of HELLP syndrome.
• Diagnostic criteria for severe preeclampsia(one of the following):
• Blood pressure of 160 mm Hg systolic or higher or 110 mm Hg diastolic or higher on two occasions at least 6 hours apart while the patient is on bed rest (unless antihypertensive therapy is intiated befor this time).
• New onest Cerebral or visual disturbances.
• Pulmonary edema or cyanosis.
• Sever persistant epigastric or right upper-quadrant pain unresponsive to medication and not accounted for by alternative diagnosis, or both.
• Impaired liver function as indicated by abnormally elevated blood concentration of liver enzymes (to twic normal concentration).
• Thrombocytopenia (platlet count less than 100, 000 per microliter.
• Diagnostic criteria for HELLP syndrome:
• Hemolysis documented by an increased LDH level and progressive anemia .
• Hepatic dysfunction documented by an LDH level \>600 IU/L, elevated liver enzymes documented by AST \>40 IU/L, ALT\>40 IU/L, or both .
• Thrombocytopenia documented by a platelet nadir less than 150, 000 cells/mm³. Thrombocytopenia is subclassified as class one HELLP syndrome: platelet nadir ≤50, 000 cells/mm³, class two HELLP syndrome: platelet nadir ≤100, 000 cells/mm³, or class three HELLP syndrome: platelet nadir ≤150, 000 cells/mm³..
• Anticepation of Microangiopathic Hemolytic Anemia:
• Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome should be considered in all pregnant women with severe thrombocytopenia, severe anemia, and elevated lactate dehydrogenase enzyme.