To compare the dose related acute effects of inhaled THC, administered through a vaporizer over approximately 20 minutes, between HC and euthymic BD individuals (referred to as eBD) on a range of subjective and objective parameters as described below:
Primary Aims:
* Verbal memory, measured by a modified computer version of the Rey Auditory Verbal Learning Test (RAVLT) and/or the CogState battery, administered while EEG data is collected.
* Executive functioning measured by the CogState battery and/or Trails Making Test-Part B.
Secondary Aims:
* Attention, measured by the Continuous Performance Test-Identical Pairs (CPT-IP).
* Working memory, measured by the Wechsler Memory Scale-3 Letter-Number Sequencing.
* Mood, measured by the Profile of Mood States (POMS).
* Psychotic-type experiences, measured by the Psychotomimetic States Inventory (PSI) and/or the Clinician Administered Dissociative Symptoms Scale (CADSS).
* Anxiety symptoms, measured by the Visual Analog Scale for Anxiety (VAS-A).
* Impulsivity, measured by the Balloon Analogue Risk Task (BART).
Exploratory aims:
•Serum prolactin, serum ACTH, serum cortisol and serum endocannabinoid levels.
