Chidamide With R-CHOP Regimen for DLBCL Patients

Exclusion Criteria

• •1. History of autologous stem cell transplantation;
• •2. History of other malignant tumors, except skin basal cell carcinoma and in situ cervical cancer;
• •3. With uncontrolled cardiovascular/ cerebrovascular disease, coagulation disorders, connective tissue disease, severe infectious diseases;
• •4. Lymphoma originated in the central nervous system;
• •5. Left ventricular ejection fraction ≦50％
• •6. Abnormal lab results in enrollment:
• •1. Neutrophil count: \<1.5\*109/L；
• •2. Platelet count \<75\*109/L；
• •3. AST or ALT \>2 times the upper limit of normal level，AKP and total bilirubin \>1.5 times the upper limit of normal level;
• •4. serum creatinine \>1.5 times the upper limit of normal level;
• •7. Other uncontrolled medical conditions which the investigators think might influence the results of the trial;
• •8. Patients with mental illnesses or other diseases that might not comply with the trial plan;
• •9. Women during pregnancy or lactation;
• •10. HIV positive patients;
• •11. HbsAg (+) patients with HBV DNA(+), can be enrolled only when his/her HBV DNA turns negative; patients with HBsAg(-) HBcAb(+) can be enrolled only when his/her HBV DNA turns negative;