Combination Latency Reversal With High Dose Disulfiram Plus Vorinostat in HIV-infected Individuals on ART

Exclusion Criteria

• •Current alcohol use disorder or hazardous alcohol use (\>7 drinks per week for women or \> 14 drinks per week for men) as determined by clinical evaluation
• •Current or recent (in the last 4 days) use of metronidazole or any drug formulation that contains alcohol or that might contain alcohol, including the gelatin capsule and liquid formulations of ritonavir, ritonavir/lopinavir, amprenavir and fosamprenavir, and alcohol-containing preparations such as cough syrups, tonics etc.
• •Current use of tipranavir or Maraviroc
• •Current use of zidovudine, stavudine or didanosine (as disulfiram potentially has potent irreversible inhibitory effects on mitochondrial metabolism and hence could exacerbate the toxicity of these drugs)
• •Concurrent use of rivaroxaban (a CYP3A metabolized medication) as the cytochrome P450 inhibitory effects of disulfiram on rivaroxaban are unknown
• •Current use of warfarin
• •Individuals who intend to modify antiretroviral therapy during the study period for any reason
• •Significant myocardial disease (current myocarditis or reduced left ventricular ejection fraction below the lower limit of normal) or diagnosed coronary artery disease
• •Significant renal disease (eGFR \<50 milliliter/minute)
• •History of psychosis, seizure disorder, abnormal electroencephalogram or brain damage with significant persisting neurological deficit
• •Prior malignancy active within the previous 3 years except for local curable cancers that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer or carcinoma in situ of the prostate, cervix or breast.
• •Known hypersensitivity to disulfiram or vorinostat or contraindications to treatment with these agents
• •Participation in another latency reversal study or receipt of vorinostat or disulfiram in the previous 12 months before starting the investigational treatment
• •Any significant acute medical illness requiring hospitalization within preceding 8 weeks
• •Hepatitis B (HBV) or hepatitis C (HCV) co-infection as determined by detection of HBsAg or HCV RNA (Individuals with prior hepatitis infection that is now cleared are eligible for enrolment)
• •Receipt of immunomodulating agents (excluding immunization) or systemic chemotherapeutic agents within 28 days prior to study entry
• •Current or recent gastrointestinal disease or surgery that may impact the absorption of the investigational drug
• •Active substance use that in the opinion of the investigator will prevent adequate compliance with study procedures
• •Women who are currently pregnant or breastfeeding
• •Women of Child Bearing Potential (WOCBP) who are unwilling or unable to use an acceptable method of contraception to avoid pregnancy
• •Unable or unwilling to adhere to protocol procedures
• •The following laboratory values within 6 weeks before starting the investigational drug (lab tests may be repeated to obtain acceptable values before failure at screening is concluded)
• •* Hepatic transaminases (AST or ALT) ≥3 x upper limit of normal (ULN)
• •* Serum total bilirubin ≥1.5 x ULN
• •* eGFR \<50 milliliter/min
• •* Hemoglobin \<11.0 g/deciliter
• •* Platelet count ≤100 x10\^9/L (liter)
• •* Absolute neutrophil count ≤1.5x10\^9/L
• •* Serum potassium, magnesium, phosphorus outside normal limits
• •* Total calcium (corrected for serum albumin) or ionized calcium ≤ lower normal limits