Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer

Exclusion Criteria

• •Have a confirmed brain tumor or brain metastases
• •Be taking a regular daily dose of an NSAID NOTE: Daily doses of 81 mg aspirin are permitted and higher doses of an NSAID on an 'as needed' basis are permitted
• •Be diagnosed with dementia or severe neurodegenerative disease
• •Have a contraindication to NSAIDs at the oncologist's discretion (i.e., allergy, worsening of ongoing medical problem due to NSAID, very low platelet count from chemotherapy, full-dose anti-coagulation/high risk of bleeding, and uncontrolled conditions such as hypertension, asthma, or peptic ulcer disease)
• •Have been hospitalized for treatment of a major psychiatric illness within the last five years
• •Have a serum creatinine above 1.5 upper limit of normal (ULN) (collected within the past 4 weeks); ULN is per institutional definition
• •Concurrent administration of warfarin, full dose aspirin, clopidogrel, apixaban or other medications known to increase the risk of bleeding or to interfere with antiplatelet activities
• •Be colorblind
• •Have active substance abuse (e.g. alcohol, drugs) per self-report or medical record