Modeling Bronchial Epithelium Modifications Associated With COPD Using iPS

Inclusion Criteria

• •The patient has given his/her signed, informed consent
• •Forced expiratory volume in 1 second / forced vital capacity \< 0.7 \[FEV1/FVC \< 0.7\]
• •FEV1 \< 50% of predicted value
• •Exclusion of other respiratory pathologies, based on anamnesis, computed tomography and complementary respiratory function tests and transthoracic ultrasound,
• •Smoking \>10 pack-years, ongoing or weaned
• •Absence of exacerbation or intercurrent infectious episode for at least 4 weeks at time of inclusion
• •Medical indication for a bronchial fibroscopy (indication validated by the physician in charge of the patient and the study investigating physician): pulmonary peripheral nodule exploration with computed tomography, interventional endoscopy for emphysema reduction, removal of foreign bodies, other indications.
• •Absence of contraindications for bronchial biopsy (left to physician's discretion): not limited to: regular intake of anticoagulants or anti-platelet aggregation, hemostasis abnormalities
• •The patient has given his/her signed, informed consent
• •Forced expiratory volume in 1 second / forced vital capacity \> 0.7 \[FEV1/FVC \> 0.7\]
• •FEV1 \> 80% of predicted value
• •Exclusion of other respiratory pathologies, based on anamnesis, computed tomography (absence of extensive emphysema lesions defined by the presence of less than \<5% relative surface area occupied by densities less than 910 UH (measured on millimeter cuts)) and respiratory function tests (Residual Volume \<120%, Diffusion Capacity for Carbon Monoxide \> 60% and Total Pulmonary Capacity\> 120%) and transthoracic ultrasound (normal),
• •Smoking \>40 pack-years, ongoing or weaned
• •Absence of exacerbation or intercurrent infectious episode for at least 4 weeks at time of inclusion
• •Medical indication for a bronchial fibroscopy (indication validated by the physician in charge of the patient and the study investigating physician): pulmonary peripheral nodule exploration with computed tomography, interventional endoscopy for emphysema reduction, removal of foreign bodies, other indications.
• •Absence of contraindications for bronchial biopsy (left to physician's discretion): not limited to: regular intake of anticoagulants or anti-platelet aggregation, hemostasis abnormalities