Evaluate Safety and Effectiveness of XenoSure Biological Patch in the Application of Cardiac Repair

Exclusion Criteria

• •1. Patients with severe visceral diseases in liver, kidney, etc.
• •2. Patients have unstable vital signs and not suitable for the indications.
• •3. Patients with severe allergic history (especially allergic to bovine materials)
• •4. Patients with the past medical history of severe immunodeficiency disease
• •5. The subject has used or plans to use immunomodulatory drugs for more than half a year.
• •6. The subject with poor blood clotting function, which is defined as that pre-operative INR or APTT is prolonged over 30% than the reference value without drug intervention, or that blood platelet count is less than 100\*10\^9/L.
• •7. The subject has severe kidney disorders or diseases with the estimated glomerular filtration rate \[GRF\]\<30mL/min/1.73m2.
• •8. The subject's ALT or AST level is 2.5 times higher than the upper normal limit or the subject has active liver disease or icterus.
• •9. The subject has participated in another clinical study within past 3 months or is participating in another clinical study now.
• •10. The investigator believes that the subject has other reasons unsuitable for inclusion.